Naslov
A novel approach for monitoring writing interferences during navigated transcranial magnetic stimulation mappings of writing related cortical areas

Autori
Rogić Vidaković, Maja ; Gabelica, Dragan ; Vujović, Igor ; Šoda, Joško ; Batarelo, Nikolina ; Džimbeg, Andrija ; Zmajević Schönwald, Marina ; Rotim, Krešimir ; Đogaš, Zoran

Izvornik
Journal of neuroscience methods (0165-0270) 255 (2015); 139-150

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
writing; transcranial magnetic stimulation; preoperative planning; language mapping; dysgraphia; Power Spectrum Density

Sažetak
It has recently been shown that navigated repetitive transcranial magnetic stimulation (nTMS) is useful in preoperative neurosurgical mapping of motor and language brain areas. In TMS mapping of motor cortices the evoked responses can be quantitatively monitored by electromyographic (EMG) recordings. No such setup exists for monitoring of writing during nTMS mappings of writing related cortical areas. We present a novel approach for monitoring writing during nTMS mappings of motor writing related cortical areas. To our best knowledge, this is the first demonstration of quantitative monitoring of motor evoked responses from hand by EMG, and of pen related activity during writing with our custom made pen, together with the application of chronometric TMS design and patterned protocol of rTMS. The method was applied in four healthy subjects participating in writing during nTMS mapping of the premotor cortical area corresponding to BA 6 and close to the superior frontal sulcus. The results showed that stimulation impaired writing in all subjects. The corresponding spectra of measured signal related to writing movements was observed in the frequency band 0-20 Hz. Magnetic stimulation affected writing by suppressing normal writing frequency band. The proposed setup for monitoring of writing provides additional quantitative data for monitoring and the analysis of rTMS induced writing response modifications. The setup can be useful for investigation of neurophysiologic mechanisms of writing, for therapeutic effects of nTMS, and in preoperative mapping of language cortical areas in patients undergoing brain surgery.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Računarstvo, Temeljne medicinske znanosti

Napomena
These authors Maja Rogić Vidaković and Dragan Gabelica contributed equally to this work.

POVEZANOST RADA