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Pregled bibliografske jedinice broj: 770158

Comprehensive genomic profiles of small cell lung cancer

George, Julie; Lim, Jing Shan; Jang, Se Jin; Cun, Yupeng; Ozretić, Luka; Kong, Gu; Leenders, Frauke; Lu, Xin; Fernández-Cuesta, Lynnette; Bosco, Graziella et al.
Comprehensive genomic profiles of small cell lung cancer // Nature, 524 (2015), 7563; 47-53 doi:10.1038/nature14664 (međunarodna recenzija, članak, znanstveni)

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Naslov
Comprehensive genomic profiles of small cell lung cancer

Autori
George, Julie ; Lim, Jing Shan ; Jang, Se Jin ; Cun, Yupeng ; Ozretić, Luka ; Kong, Gu ; Leenders, Frauke ; Lu, Xin ; Fernández-Cuesta, Lynnette ; Bosco, Graziella ; Müller, Christian ; Dahmen, Ilona ; Jahchan, Nadine S. ; Park, Kwon-Sik ; Yang, Dian ; Karnezis, Anthony N. ; Vaka, Dedeepya ; Torres, Angela ; Wang, Maia Segura ; Korbel, Jan O. ; Menon, Roopika ; Chun, Sung-Min ; Kim, Deokhoon ; Wilkerson, Matt ; Hayes, Neil ; Engelmann, David ; Pützer, Brigitte ; Bos, Marc ; Michels, Sebastian ; Vlašić, Ignacija ; Seidel, Danila ; Pinther, Berit ; Schaub, Philipp ; Becker, Christian ; Altmüller, Janine ; Yokota, Jun ; Kohno, Takashi ; Iwakawa, Reika ; Tsuta, Koji ; Noguchi, Masayuki ; Muley, Thomas ; Hoffmann, Hans ; Schnabel, Philipp A ; Petersen, Iver ; Chen, Yuan ; Soltermann, Alex ; Tischler, Verena ; Choi, Chang-min ; Kim, Yong-Hee ; Massion, Pierre P. ; Zou, Yong ; Jovanović, Dragana ; Kontić, Milica ; Wright, Gavin M. ; Russell, Prudence A ; Solomon, Benjamin ; Koch, Ina ; Lindner, Michael ; Muscarella, Lucia A ; la Torre, Annamaria ; Field, John K ; Jakopović, Marko ; Knežević, Jelena ; Castaños-Vélez, Esmeralda ; Roz, Luca ; Pastorino, Ugo ; Brustugun, Odd-Terje ; Lund-Iversen, Marius ; Thunnissen, Erik ; Köhler, Jens ; Schuler, Martin ; Botling, Johan ; Sandelin, Martin ; Sanchez-Cespedes, Montserrat ; Salvesen, Helga B ; Achter, Viktor ; Lang, Ulrich ; Bogus, Magdalena ; Schneider, Peter M. ; Zander, Thomas ; Ansén, Sascha et al.

Izvornik
Nature (0028-0836) 524 (2015), 7563; 47-53

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Comprehensive genomic profiles; Small cell lung cancer; TP53 and RB1 tumor supressors

Sažetak
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Jelena Knežević (autor)

Avatar Url Ignacija Vlašić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

George, Julie; Lim, Jing Shan; Jang, Se Jin; Cun, Yupeng; Ozretić, Luka; Kong, Gu; Leenders, Frauke; Lu, Xin; Fernández-Cuesta, Lynnette; Bosco, Graziella et al.
Comprehensive genomic profiles of small cell lung cancer // Nature, 524 (2015), 7563; 47-53 doi:10.1038/nature14664 (međunarodna recenzija, članak, znanstveni)
George, J., Lim, J., Jang, S., Cun, Y., Ozretić, L., Kong, G., Leenders, F., Lu, X., Fernández-Cuesta, L. & Bosco, G. (2015) Comprehensive genomic profiles of small cell lung cancer. Nature, 524 (7563), 47-53 doi:10.1038/nature14664.
@article{article, author = {George, Julie and Lim, Jing Shan and Jang, Se Jin and Cun, Yupeng and Ozreti\'{c}, Luka and Kong, Gu and Leenders, Frauke and Lu, Xin and Fern\'{a}ndez-Cuesta, Lynnette and Bosco, Graziella and M\"{u}ller, Christian and Dahmen, Ilona and Jahchan, Nadine S. and Park, Kwon-Sik and Yang, Dian and Karnezis, Anthony N. and Vaka, Dedeepya and Torres, Angela and Wang, Maia Segura and Korbel, Jan O. and Menon, Roopika and Chun, Sung-Min and Kim, Deokhoon and Wilkerson, Matt and Hayes, Neil and Engelmann, David and P\"{u}tzer, Brigitte and Bos, Marc and Michels, Sebastian and Vla\v{s}i\'{c}, Ignacija and Seidel, Danila and Pinther, Berit and Schaub, Philipp and Becker, Christian and Altm\"{u}ller, Janine and Yokota, Jun and Kohno, Takashi and Iwakawa, Reika and Tsuta, Koji and Noguchi, Masayuki and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Petersen, Iver and Chen, Yuan and Soltermann, Alex and Tischler, Verena and Choi, Chang-min and Kim, Yong-Hee and Massion, Pierre P. and Zou, Yong and Jovanovi\'{c}, Dragana and Konti\'{c}, Milica and Wright, Gavin M. and Russell, Prudence A and Solomon, Benjamin and Koch, Ina and Lindner, Michael and Muscarella, Lucia A and la Torre, Annamaria and Field, John K and Jakopovi\'{c}, Marko and Kne\v{z}evi\'{c}, Jelena and Casta\~{n}os-V\'{e}lez, Esmeralda and Roz, Luca and Pastorino, Ugo and Brustugun, Odd-Terje and Lund-Iversen, Marius and Thunnissen, Erik and K\"{o}hler, Jens and Schuler, Martin and Botling, Johan and Sandelin, Martin and Sanchez-Cespedes, Montserrat and Salvesen, Helga B and Achter, Viktor and Lang, Ulrich and Bogus, Magdalena and Schneider, Peter M. and Zander, Thomas and Ans\'{e}n, Sascha et al.}, year = {2015}, pages = {47-53}, DOI = {10.1038/nature14664}, keywords = {Comprehensive genomic profiles, Small cell lung cancer, TP53 and RB1 tumor supressors}, journal = {Nature}, doi = {10.1038/nature14664}, volume = {524}, number = {7563}, issn = {0028-0836}, title = {Comprehensive genomic profiles of small cell lung cancer}, keyword = {Comprehensive genomic profiles, Small cell lung cancer, TP53 and RB1 tumor supressors} }
@article{article, author = {George, Julie and Lim, Jing Shan and Jang, Se Jin and Cun, Yupeng and Ozreti\'{c}, Luka and Kong, Gu and Leenders, Frauke and Lu, Xin and Fern\'{a}ndez-Cuesta, Lynnette and Bosco, Graziella and M\"{u}ller, Christian and Dahmen, Ilona and Jahchan, Nadine S. and Park, Kwon-Sik and Yang, Dian and Karnezis, Anthony N. and Vaka, Dedeepya and Torres, Angela and Wang, Maia Segura and Korbel, Jan O. and Menon, Roopika and Chun, Sung-Min and Kim, Deokhoon and Wilkerson, Matt and Hayes, Neil and Engelmann, David and P\"{u}tzer, Brigitte and Bos, Marc and Michels, Sebastian and Vla\v{s}i\'{c}, Ignacija and Seidel, Danila and Pinther, Berit and Schaub, Philipp and Becker, Christian and Altm\"{u}ller, Janine and Yokota, Jun and Kohno, Takashi and Iwakawa, Reika and Tsuta, Koji and Noguchi, Masayuki and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Petersen, Iver and Chen, Yuan and Soltermann, Alex and Tischler, Verena and Choi, Chang-min and Kim, Yong-Hee and Massion, Pierre P. and Zou, Yong and Jovanovi\'{c}, Dragana and Konti\'{c}, Milica and Wright, Gavin M. and Russell, Prudence A and Solomon, Benjamin and Koch, Ina and Lindner, Michael and Muscarella, Lucia A and la Torre, Annamaria and Field, John K and Jakopovi\'{c}, Marko and Kne\v{z}evi\'{c}, Jelena and Casta\~{n}os-V\'{e}lez, Esmeralda and Roz, Luca and Pastorino, Ugo and Brustugun, Odd-Terje and Lund-Iversen, Marius and Thunnissen, Erik and K\"{o}hler, Jens and Schuler, Martin and Botling, Johan and Sandelin, Martin and Sanchez-Cespedes, Montserrat and Salvesen, Helga B and Achter, Viktor and Lang, Ulrich and Bogus, Magdalena and Schneider, Peter M. and Zander, Thomas and Ans\'{e}n, Sascha et al.}, year = {2015}, pages = {47-53}, DOI = {10.1038/nature14664}, keywords = {Comprehensive genomic profiles, Small cell lung cancer, TP53 and RB1 tumor supressors}, journal = {Nature}, doi = {10.1038/nature14664}, volume = {524}, number = {7563}, issn = {0028-0836}, title = {Comprehensive genomic profiles of small cell lung cancer}, keyword = {Comprehensive genomic profiles, Small cell lung cancer, TP53 and RB1 tumor supressors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE
  • Nature Index

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