Naslov
IL-33-dependent immunosuppressive Treg responses to liver damage during MCMV infection

Autori
Branka Popović, Mijo Golemac, Lidija Bilić- Zulle, Miodrag Lukić, Astrid Krmpotić, Stipan Jonjić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
VISTRIE2015 Abstract book / - , 2015

Skup
3rd International Symposium of the Virtual Institute "Viral Strategies of Immune Evasion" VISTRIE

Mjesto i datum
Braunschweig, Njemačka, 22.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Interleukin-33; mouse; mouse cytomegalovirus; ST2 protein; mouse; T-lymphocytes; regulatory

Sažetak
Regulatory T cells (Treg) are critical for preventing autoimmunity mediated by self- reactive T cells, but also in modulating immune responses to infections and therefore controlling balance between activation and tolerance. Murine cytomegalovirus (MCMV) is a herpesvirus with pathogenic potential that can induce high levels of viral replication and modulate antiviral responses. Thus, early immune mechanisms are essential in controlling virus replication and protecting the host from virus-induced pathology. Studies on Treg cells reveal their role in suppressing early NK and T cell responses activated by MCMV infection. However, absence of Treg cells does not influence viral clearance. Here we show that Treg cells are indispensable for preventing liver pathology induced by MCMV infection. In addition, their suppressive capacity is dependent on tissue alarmin, IL-33, which promotes Treg recruitment and function in liver of MCMV infected mice. Moreover, mice lacking IL-33 receptor, showed higher death rate mediated by stronger liver pathology after infection with high viral dose. This is a consequence of decreased infiltration of Treg cells and lower expression of anti-inflammatory IL-10 and TGF-β, compared to control mice. In the light of recent discovery of IL-33's importance for accumulation and maintenance of Treg cells in acute colitis model, our results suggest protective and homeostatic role of IL- 33 signaling in inflammation induced by MCMV infection.

Izvorni jezik
Engleski

POVEZANOST RADA