Naslov
Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones

Autori
Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sinopsisa / Prous, J.R. - Barcelona : Drugs of the Future, 2002, 209-209

Skup
XVII International Symposium on Medicinal chemistry

Mjesto i datum
Barcelona, Španjolska, 01.09.2002. - 05.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thienothienil quinolons; antitumor activity

Sažetak
Some new polycyclic heterocyclic compounds of the quinolone type shown on Figure 1 were prepared by multistep synthesis [1]. Common feature of all the compounds synthesized is that they have at least one N-[3-(dimethylamino)propyl] group which is present in number of substances possessing antiviral activity [2]. R R’ -H -(CH2)3N(CH3)2 -COOCH3 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -(CH2)3N(CH3)2 -CONHC6H5 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -H -CON(C6H5)(CH2)3N(CH3)2 -H Figure 1. Structure of thieno[3’, 2’:4, 5]thieno[2, 3-c]quinolin-6-ones The reaction of photocyclization of anilides, acylation of amines with carboxylic chlorides and esters and N-alkylation of amides were used as a final step in the synthesis of corresponding quinolone derivatives. Prepared quinolones were tested on antitumor activity and showed very intensive action “in vitro” on some human carcinoma [3]. Testing “in vivo” is in course.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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