Naslov
Novel 2-(substituted-phenyl)-6-amino-benzothiazole hydrochlorides : synthesis and antitumor activity

Autori
Karminski-Zamola, Grace ; Racane, Livio ; Stojković, Ranko ; Tralić-Kulenović, Vesna ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the XVIIth International Symposium on Medicinal Chemistry / Prous, J.R. - Barcelona, 2002, 296-296

Skup
XVIIth International Symposium on Medicinal Chemistry

Mjesto i datum
Barcelona, Španjolska, 01.09.2002. - 05.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzothiazoles ; antitumor activity

Sažetak
A series of hydrochloride or dihydrochloride salts of the novel 2-(4-substituted-phenyl)-6-amino-benzothiazoles antitumor agents, have been prepared in multistep synthesis starting from substituted benzaldehydes and 3-nitro-substituted o-amino-thiophenol and evaluated on their antitumor activity on following malignant human tumor cell lines : cervical carcinoma (HeLa), breast carcinoma (MCF-7), colon carcinoma (CaCO-2), laryngeal carcinoma (Hep-2), as well as on human fibroblast cell lines (WI-38):

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA