Naslov
Cytochrome P450 - CYP2D6 polymorphism in head and neck cancer patients

Autori
Štefanovic, Mario ; Begonja, Antonija ; Topić, Elizabeta ; Čurčić, Ivica ; Šimundic, Ana-Maria

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics. European Human Genetics Conference 2002 in conjunction with the European Meeting on Psychosocial Aspects of Genetics 2002 / - : Nature publishing group, 2002, 110-111

Skup
European Human Genetics Conference 2002 in conjunction with the European Meeting on Psychosocial Aspects of Genetics 2002

Mjesto i datum
Strasbourg, Francuska, 25.05.2002. - 29.05.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CYP2D6; head and neck cancer

Sažetak
We investigated the possible association of drug metabolizing enzyme system CYP P450 CYP2D6 and its null alleles (CYP2D6*3, *4, *5, *6, *7, and *8) with incidence of tumors in patients having head and neck cancer (HNC). It is known that persons bearing two null alleles poorly metabolize some common drugs (Poor Metabolizer Phenotype – PM) as well as other foreign and carcinogenic substances. Persons with only one disrupted CYP2D6 gene (bearing one normal and one null allele) are considered to be Intermediate metabolizer phenotype (IM). We genotyped 145 controls, and 42 HNC patients by Multiplex Allele Specific PCR on whole blood DNA. Study results showed allelic frequencies for *3, *4 and *6 alleles (only alleles observed) in controls to be 1.4%, 11.0% and 1.0%, respectively ; among them we found 2.1% PMs and 22.8% IMs. In cancer patient’s group allelic frequencies for *3, *4 and *6 were 1.2%, 19.0% and 3, 6% respectively, and no other alleles were found ; among them we found 2.4% PMs and 42.9% IMs. Results of our study showed statistically significant difference for genotype frequencies (Chi-square ; p=0.025) and predicted phenotype (Chi-square ; p=0.034). IM phenotype showed to be responsible for increased risk to HNC (Odds ratio 2.6 ; 95%CI= 1.248 - 5.193). To confirm our preliminary findings, further study on a larger group is planned.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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