Naslov
Low neural exosomal levels of cellular survival factors inAlzheimer’s disease

Autori
Goetzl, Edward J. ; Boxer, Adam ; Schwartz, Janice B. ; Abner, Erin L. ; Petersen, Ronald C. ; Miller, Bruce L. ; Carlson, Olga D. ; Mustapić, Maja ; Kapogiannis, Dimitrios

Izvornik
Annals of clinical and translational neurology (2328-9503) 2 (2015), 7; 769-773

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
exosomes ; Alzheimer's disease ; Frontotemporal dementia ; transcription factors

Sažetak
Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1- silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA