Pregled bibliografske jedinice broj: 760472
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection // 5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop
Brisbane, Australija, 2015. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 760472 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection
Autori
Tomac, Jelena ; Juranić Lisnić, Vanda ; Bralić, Marina ; Krmpotić, Astrid ; Dölken, Lars ; Jonjić, Stipan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop
Mjesto i datum
Brisbane, Australija, 19.04.2015. - 24.04.2015
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
MCMV; ovary; follicles; corpora lutea
Sažetak
In this study we have used the murine cytomegalovirus (MCMV) model to analyze the impact of cytomegalovirus infection in early pregnancy. We have observed an overwhelming infection of ovarian corpora lutea (CL) which was in a strong contrast to the resistance of ovarian follicles to MCMV infection. The excessive infection of CL granulosa cells, the main producers of progesterone during early pregnancy, was accompanied by a substantial pregnancy loss. Microarray analysis of MCMV infected ovaries revealed a detrimental regulation of key genes involved in the synthesis and degradation of serum progesterone levels as a consequence of virus infection. In addition, we have characterized and discussed the mechanism of differential innate resistance of CL and ovarian follicles to MCMV infection which depends on the cell’s intrinsic antiviral defenses and the immune system.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1265 - Citomegalovirusna infekcija ovarija (Tomac, Jelena, MZOS ) ( CroRIS)
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Vanda Juranić Lisnić
(autor)
Astrid Krmpotić
(autor)
Stipan Jonjić
(autor)
Jelena Tomac
(autor)
Marina Bralić
(autor)