Naslov
Towards structural studies of cannabinoid CB2 and vasopressin V2 receptors

Autori
Milić, Dalibor ; Heydenreich, Franziska M. ; Miljuš, Tamara ; Veprintsev, Dmitry B.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
3rd Annual Meeting of the GDR 3545 “From Physiology to Drugs: RCPG-PHYSIO-MED”

Mjesto i datum
Montpellier, Francuska, 20.10.2014. - 22.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
V2 receptor; CB2 receptor; GPCR

Sažetak
Cannabinoid CB2 receptor and vasopressin V2 receptor are G protein-coupled receptors involved in several important physiological processes in a human organism. CB2 is a part of the “endocannabinoid system” and is predominantly present in immune and peripheral nervous systems. It is valuable drug target for treating inflammatory diseases, pain, osteoporosis, atherosclerosis and brain tumors. V2 is present in kidneys and has an important role in maintaining water homeostasis in human organism. It is targeted in treatment of diabetes insipidus and hyponatremia. In order to understand mechanisms by which different effectors modulate activities of CB2 and V2 receptors, we are aiming at determining molecular structures of these receptors with bound ligands, both agonists and antagonists. This involves stabilization and crystallization of the receptor molecules and, finally, determination of their structures by X-ray crystallography. We will present our recent advances in engineering human CB2 and V2 receptors for structural studies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA