Naslov
Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria

Autori
Ljubić, Spomenka ; Jazbec, Anamarija ; Tomić, Martina ; Piljac, Ante ; Jurišić Eržen, Dubravka ; Novak, Branko ; Kaštelan, Snježana ; Vučić Lovrenčić, Marijana ; Brkljačić, Neva

Izvornik
International journal of endocrinology (1687-8337) (2015); 372796-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adiponectin; albuminuria; diabetes mellitus

Sažetak
Aims were to investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy. ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients. Significant differences among ApN levels according to AER were found in both types of diabetes (𝐹 = 8.45, df = 2, 𝑃 < 0.001).With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (𝐹 = 12.7, df = 1, 𝑃 < 0.001). The best model for ApN (𝑅 2 = 0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (𝑅 2 = 0.2882) it included ppPG, LDL, and UA. ApNbehaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroupswith decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA