Naslov
Charged Amphiphylic Ligands of Nanoparticles Increase Lateral Compaction of Membranes. Nanomechanical and Thermotropic Study of Model Lipid Membranes in High Ionic Strength Solutions

Autori
Šegota Suzana, Vojta Danijela, Kendziora Dania, Ahmed Ishtiaq, Fruk Ljiljana, Baranović Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th Christmas Biophysics workshop / Antonio Šibe, Tomislav Vuletic - Zagreb : Croatian Biophysical Society, December 2014., 2014, 29-29

Skup
9th Christmas Biophysics workshop

Mjesto i datum
Buzet, Hrvatska, 15.12.2014. - 16.12.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Clustering; Force spectroscopy; IR spectroscopy; Nanomechanics; Nanoparticles

Sažetak
The research of the nanoparticle (NP) delivery systems and the use of NPs both for diagnostic and therapeutic purposes have created a need for understanding the complex interactions of NPs with cells. Membrane-NP interactions are of crucial importance both for the cell uptake and toxicological investigations. For that reason, lipids that are the cell membrane building blocks, have been used as simplified model systems to study not only the mechanical properties of the membranes and their interactions with different molecular species, but also their structural organization in, for example, marine ecosystems, which are particularly sensitive to the toxicological environmental effects[1]. The presence of hydrophobic NPs embedded within a lipid bilayer, can lead to rearrangement of lipid nolecules by modifying interactions amongst the lipd headgroups and/or acyl tails. Therefore, research towards the examination of interaction of NP within lipid membranes using transmission infrared spectroscopy and force spectroscopy (FS) have been undertaken. Our research deciphered interactions of hydrophobic NP with model membranes through their delicate response in physiological and seawater environment. Functionality of the NP has been related to the organisation and fluidity of the model lipid membrane. The formation of lipid/NP assemblies containing hydrophobically modified NPs showed specific effects on the later compaction of the supported lipid bilayers arround NPs in both media.

Izvorni jezik
Engleski

POVEZANOST RADA