Naslov
DPC4 tumor suppressor gene in human sporadic colon cancer ; loss of heterozygosity

Autori
Popović Hadžija, Marijana ; Kapitanović, Sanja ; Radošević, Senka ; Čačev, Tamara ; Spaventi, Radan ; Hadžija, Mirko ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 10th International congress of human genetics in European Journal of Human Genetics / - Beč : Nature publishing group, 2001, 124-125

Skup
International congress of human genetics (10 ; 2001)

Mjesto i datum
Beč, Austrija, 15.05.2001. - 19.05.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DPC4; LOH; sporadic colon cancer

Sažetak
The most frequently affected regions in colorectal tumors are chrosomes 17p and 18q, where DPC4 gene exist. The purpose was to examine the prevalence of DPC4 loss of heterozygosity (LOH) in sporadic colon cancer. We examined 36 samples of human sporadic colon carcinoma of Croatian patients and corresponding normal tissue. Each sample was tested for LOH using threee polymorphic markers. Informativity was observed in 97% of analyzed samples. LOH at the DPC4 locus was detected in 51% of informative tumors. We concluded that inactivation of the DPC4 gene play a role in a multistep process of colon cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA