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Pregled bibliografske jedinice broj: 756411

The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells

Stuparević, Igor; Becker, E.; Law, M.J.; Primig, M.
The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells // FEBS letters, 589 (2015), 8; 924-932 doi:10.1016/j.febslet.2015.02.022 (međunarodna recenzija, članak, znanstveni)

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Naslov
The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells

Autori
Stuparević, Igor ; Becker, E. ; Law, M.J. ; Primig, M.

Izvornik
FEBS letters (0014-5793) 589 (2015), 8; 924-932

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5′-UTR ; Isoform ; RPD3 ; UME6 ; VTH1 ; VTH2

Sažetak
The tripartite Rpd3/Sin3/Ume6 complex represses meiotic isoforms during mitosis. We asked if it also controls starvation-induced isoforms. We report that VTH1/VTH2 encode acetate-inducible isoforms with extended 5'-regions overlapping antisense long non-coding RNAs. Rpd3 and Ume6 repress the long isoform of VTH2 during fermentation. Cells metabolising glucose contain Vth2, while the protein is undetectable in acetate and during sporulation. VTH2 is a useful model locus to study mechanisms implicating promoter directionality, lncRNA transcription and post- transcriptional control of gene expression via 5'- UTRs. Since mammalian genes encode transcript isoforms and Rpd3 is conserved, our findings are relevant for gene expression in higher eukaryotes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija



POVEZANOST RADA

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Profili:

Avatar Url Igor Stuparević (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com

Citiraj ovu publikaciju:

Stuparević, Igor; Becker, E.; Law, M.J.; Primig, M.
The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells // FEBS letters, 589 (2015), 8; 924-932 doi:10.1016/j.febslet.2015.02.022 (međunarodna recenzija, članak, znanstveni)
Stuparević, I., Becker, E., Law, M. & Primig, M. (2015) The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells. FEBS letters, 589 (8), 924-932 doi:10.1016/j.febslet.2015.02.022.
@article{article, author = {Stuparevi\'{c}, Igor and Becker, E. and Law, M.J. and Primig, M.}, year = {2015}, pages = {924-932}, DOI = {10.1016/j.febslet.2015.02.022}, keywords = {5′-UTR, Isoform, RPD3, UME6, VTH1, VTH2}, journal = {FEBS letters}, doi = {10.1016/j.febslet.2015.02.022}, volume = {589}, number = {8}, issn = {0014-5793}, title = {The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells}, keyword = {5′-UTR, Isoform, RPD3, UME6, VTH1, VTH2} }
@article{article, author = {Stuparevi\'{c}, Igor and Becker, E. and Law, M.J. and Primig, M.}, year = {2015}, pages = {924-932}, DOI = {10.1016/j.febslet.2015.02.022}, keywords = {5′-UTR, Isoform, RPD3, UME6, VTH1, VTH2}, journal = {FEBS letters}, doi = {10.1016/j.febslet.2015.02.022}, volume = {589}, number = {8}, issn = {0014-5793}, title = {The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells}, keyword = {5′-UTR, Isoform, RPD3, UME6, VTH1, VTH2} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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