Naslov
Advances in peptide-based DNA/RNA-intercalators

Autori
Matić, Josipa ; Tumir, Lidija-Marija ; Radić Stojković, Marijana ; Piantanida, Ivo

Izvornik
Current protein & peptide science (1389-2037) 17 (2016), 2; 127-134

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA ; RNA ; peptide ; intercalator ; fluorescence ; DNA-cleavage

Sažetak
Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components ; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA