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Pregled bibliografske jedinice broj: 755873

Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome

Pikija, Slaven; Cvetko, Danijel; Hajduk, Martina; Trkulja, Vladimir
Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome // Clinical neurology and neurosurgery (Dutch-Flemish ed.), 111 (2009), 7; 568-573 doi:10.1016/j.clineuro.2009.04.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome
(Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome.)

Autori
Pikija, Slaven ; Cvetko, Danijel ; Hajduk, Martina ; Trkulja, Vladimir

Izvornik
Clinical neurology and neurosurgery (Dutch-Flemish ed.) (0303-8467) 111 (2009), 7; 568-573

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ischemic stroke; Stroke outcome; Infarct volume; CT brain scan; Platelets; Mean platelet volume

Sažetak
Mean platelet volume (MPV) determined shortly after the onset of acute ischemic stroke represents the pre-stroke values. Data on its relationship to stroke severity/outcome have been conflicting. We related MPV to infarct volume on CT brain scans and risk of death/dependence 7 days and 3 months post-stroke. MPV (within 30 h since stroke onset), infarct volume (13–83 h since stroke onset) and clinical outcomes were evaluated in 81 consecutive patients (32 men, age 52–91 years, 10 small artery occlusion, 10 large artery atherosclerosis, 29 cardioembolic, 32 multiple probable/possible etiology). Higher MPV was independently associated with larger ln-infarct volume [estimate 0.259, 95% confidence interval (CI) 0.004–0.513, P = 0.046], greater risk of death/dependence 7 days post-stroke [relative risk (RR) = 1.077, 95% CI 1.005–1.115, P = 0.036], and greater risk of death/dependence 3 months post-stroke (RR = 1.077, 95% CI 1.001–1.158, P = 0.048). Considered covariates: stroke etiology, CT scan timing, platelet count and other hematological parameters, demographic variables, history of cerebrovascular, cardiac or cardiovascular diseases, diabetes, serum chemistry, previous antiplatelet and statin use and treatments delivered after the index event. Data support the view about MPV as a determinant of severity/outcome of the acute ischemic stroke.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Opća bolnica Varaždin

Profili:

Avatar Url Vladimir Trkulja (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Pikija, Slaven; Cvetko, Danijel; Hajduk, Martina; Trkulja, Vladimir
Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome // Clinical neurology and neurosurgery (Dutch-Flemish ed.), 111 (2009), 7; 568-573 doi:10.1016/j.clineuro.2009.04.002 (međunarodna recenzija, članak, znanstveni)
Pikija, S., Cvetko, D., Hajduk, M. & Trkulja, V. (2009) Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clinical neurology and neurosurgery (Dutch-Flemish ed.), 111 (7), 568-573 doi:10.1016/j.clineuro.2009.04.002.
@article{article, author = {Pikija, Slaven and Cvetko, Danijel and Hajduk, Martina and Trkulja, Vladimir}, year = {2009}, pages = {568-573}, DOI = {10.1016/j.clineuro.2009.04.002}, keywords = {Ischemic stroke, Stroke outcome, Infarct volume, CT brain scan, Platelets, Mean platelet volume}, journal = {Clinical neurology and neurosurgery (Dutch-Flemish ed.)}, doi = {10.1016/j.clineuro.2009.04.002}, volume = {111}, number = {7}, issn = {0303-8467}, title = {Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome}, keyword = {Ischemic stroke, Stroke outcome, Infarct volume, CT brain scan, Platelets, Mean platelet volume} }
@article{article, author = {Pikija, Slaven and Cvetko, Danijel and Hajduk, Martina and Trkulja, Vladimir}, year = {2009}, pages = {568-573}, DOI = {10.1016/j.clineuro.2009.04.002}, keywords = {Ischemic stroke, Stroke outcome, Infarct volume, CT brain scan, Platelets, Mean platelet volume}, journal = {Clinical neurology and neurosurgery (Dutch-Flemish ed.)}, doi = {10.1016/j.clineuro.2009.04.002}, volume = {111}, number = {7}, issn = {0303-8467}, title = {Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome.}, keyword = {Ischemic stroke, Stroke outcome, Infarct volume, CT brain scan, Platelets, Mean platelet volume} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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