Naslov
Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide

Autori
Baretić, Maja ; Pavlić-Renar, Ivana ; Aganović, Izet

Izvornik
Diabetologia Croatica (0351-0042) 42 (2013), 3; 67-71

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
exenatide; blood pressure; weight loss

Sažetak
Exenatide treatment is related to lower blood pressure. It is explained by different pathophysiological pathways. We explored the dynamics of blood pressure and weight loss during one-year therapy with exenatide. Forty-nine type 2 diabetic patients previously treated with a combination of metformin and sulfonylurea were included in this open-label, intention to treat study. Five mg of exenatide was administered twice daily for 4 weeks, and then 10 mg twice daily as adjunctive therapy to the pre-existing treatment. Patients in whom antihypertensive therapy was modified were excluded from analysis. At the end of 52 weeks, systolic blood pressure decreased significantly, with a 4.65 mm Hg reduction (P=0.008582) in exenatide treated patients. There was a positive correlation between body weight and systolic blood pressure drop (Pearson coefficient 0.675254). The interesting blood pressure curve could have relied on various antihypertensive mechanisms of exenatide: drop of blood pressure at first 16 weeks could have been connected with natriuresis and the second one with later vasodilatation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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