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Pregled bibliografske jedinice broj: 753411

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

Gur, C; Ibrahim, Y; Isaacson, B; Yamin, R; Abed, J; Gamliel, M; Enk, J; Bar-On, Y; Stanietsky-Kaynan, N; Coppenhagen-Glazer, S et al.
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack // Immunity, 42 (2015), 2; 344-55 doi:10.1016/j.immuni (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 753411 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

Autori
Gur, C ; Ibrahim, Y ; Isaacson, B ; Yamin, R ; Abed, J ; Gamliel, M ; Enk, J ; Bar-On, Y ; Stanietsky-Kaynan, N ; Coppenhagen-Glazer, S ; Shussman, N ; Almogy, G ; Cuapio, A ; Hofer, E ; Mevorach, D ; Tabib, A ; Ortenberg, R ; Markel, G ; Miklić, Karmela ; Jonjić, Stipan ; Brennan, CA ; Garrett, WS ; Bachrach, G ; Mandelboim, O

Izvornik
Immunity (1074-7613) 42 (2015), 2; 344-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cells; Fap2 protein; TIGIT

Sažetak
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we have shown that natural killer (NK) cell killing of various tumors is inhibited in the presence of various F. nucleatum strains. Our data support that this F. nucleatum-mediated inhibition is mediated by human, but not by mouse TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Using a library of F. nucleatum mutants, we found that the Fap2 protein of F. nucleatum directly interacted with TIGIT, leading to the inhibition of NK cell cytotoxicity. We have further demonstrated that tumor-infiltrating lymphocytes expressed TIGIT and that T cell activities were also inhibited by F. nucleatum via Fap2. Our results identify a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Gur, C; Ibrahim, Y; Isaacson, B; Yamin, R; Abed, J; Gamliel, M; Enk, J; Bar-On, Y; Stanietsky-Kaynan, N; Coppenhagen-Glazer, S et al.
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack // Immunity, 42 (2015), 2; 344-55 doi:10.1016/j.immuni (međunarodna recenzija, članak, znanstveni)
Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N. & Coppenhagen-Glazer, S. (2015) Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity, 42 (2), 344-55 doi:10.1016/j.immuni.
@article{article, author = {Gur, C and Ibrahim, Y and Isaacson, B and Yamin, R and Abed, J and Gamliel, M and Enk, J and Bar-On, Y and Stanietsky-Kaynan, N and Coppenhagen-Glazer, S and Shussman, N and Almogy, G and Cuapio, A and Hofer, E and Mevorach, D and Tabib, A and Ortenberg, R and Markel, G and Mikli\'{c}, Karmela and Jonji\'{c}, Stipan and Brennan, CA and Garrett, WS and Bachrach, G and Mandelboim, O}, year = {2015}, pages = {344-55}, DOI = {10.1016/j.immuni}, keywords = {NK cells, Fap2 protein, TIGIT}, journal = {Immunity}, doi = {10.1016/j.immuni}, volume = {42}, number = {2}, issn = {1074-7613}, title = {Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack}, keyword = {NK cells, Fap2 protein, TIGIT} }
@article{article, author = {Gur, C and Ibrahim, Y and Isaacson, B and Yamin, R and Abed, J and Gamliel, M and Enk, J and Bar-On, Y and Stanietsky-Kaynan, N and Coppenhagen-Glazer, S and Shussman, N and Almogy, G and Cuapio, A and Hofer, E and Mevorach, D and Tabib, A and Ortenberg, R and Markel, G and Mikli\'{c}, Karmela and Jonji\'{c}, Stipan and Brennan, CA and Garrett, WS and Bachrach, G and Mandelboim, O}, year = {2015}, pages = {344-55}, DOI = {10.1016/j.immuni}, keywords = {NK cells, Fap2 protein, TIGIT}, journal = {Immunity}, doi = {10.1016/j.immuni}, volume = {42}, number = {2}, issn = {1074-7613}, title = {Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack}, keyword = {NK cells, Fap2 protein, TIGIT} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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