Naslov
Natural zeolite clinoptilolite: new adjuvant in anticancer therapy

Autori
Pavelić, Krešimir ; Hadžija, Mirko ; Bedrica, Ljiljana ; Pavelić, Jasminka ; Đikić, Ivan ; Katić, Maša ; Kralj, Marijeta ; Herak Bosnar, Maja ; Kapitanović, Sanja ; Poljak-Blaži, Marija ; Križanac, Šimun ; Stojković, Ranko ; Jurin, Mislav ; Subotić, Boris ; Čolić, Miroslav

Izvornik
Journal of Molecular Medicine (0946-2716) 78 (2001), 12; 708-720

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
clinoptilolite; adjuvant; anticancer; treatment

Sažetak
Natural silicate materials, including zeolite clinoptilolite, have been shown to exhibit diverse biological activities and have been used successfully as a vaccine adjuvant and for the treatment of diarrhea. We report a novel use of finely ground clinoptilolite as a potential adjuvant in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering from a variety of tumor types led to improvement in the overall health status, prolongation of life-span, and decrease in tumors size. Local application of clinoptilolite to skin cancers of dogs effectively reduced tumor formation and growth. In addition, toxicology studies on mice and rats demonstrated that the treatment does not have negative effects. In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cencer cell lines. These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA