Naslov
Molecular epidemiology of human pathogenic “ArboRobo-viruses” in Croatia

Autori
Kurolt, Ivan-Christian ; Cvetko Krajinović, Lidija ; Tadin, Ante ; Svoboda, Petra ; Bjedov, Linda ; Vucelja, Marko ; Habušs, Josipa ; Štritof Majetić, Zrinka ; Kuzman, Ilija ; Margaletić, Josip ; Turk, Nenad ; Betica-Radić, Ljiljana ; Krajinović, Vladimir ; Topić, Antea ; Baršić, Bruno ; Merdić, Enrih ; Landeka, Nediljko ; Markotić, Alemka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st CroViWO - Croatian Virus Workshop - Book of Abstracts / Vanda Juranić Lisnić, Igor Jurak and Dijana Škorić - : Hrvatsko mikrobiološko društvo, 2014, 15-16

ISBN
978-953-7778-09-5

Skup
1st CroViWo - Croatian Virus Workshop - Basic and Translational Virus Research

Mjesto i datum
Rijeka, Hrvatska, 14.11.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Arboviruses; Roboviruses; arthropods; rodents; zoonoses

Sažetak
Many zoonotic viruses are transmitted by arthropode vectors (e.g. mosquitoes and ticks) between their reservoir hosts and humans and are therefore called arboviruses. This non- systemic classification comprises approximatley 250 different virus species, 80 of them being pathogenic for humans, for example: Dengue virus or Chikungunya virus. Similarly the term roboviruses describes zoonotic viruses that are being transmitted by rodents. Human pathogenic roboviruses belong to two genera, Hantavirus and Arenavirus. The newly coined term ArboRoboviruses includes all viruses from both groups that are mostly emerging or re-emerging pathogens. We will focus here on molecular epidemiology of several emerging and re- emerging ArboRoboviruses in Croatia. Hantaviruses cause hemorrhagic fever with renal syndrome, which was described in Croatia in the 1960’s. Since then several epidemics occurred caused by Puumala and Dobrava viruses. Additionally were Tula and Saarema viruses in small rodents detected. The percentage of infected small rodents varies between different hantaviruses and regions and can reach up to 77 %. Molecular epidemiology showed that Puumala virus at higher altitudes of Gorski Kotar represent a phylogenetically distinct clade in comparison to low-land Puumala viruses. In 2010 three cases of autochthonous Dengue virus infection were discovered at the Pelješac peninsula. Molecular characterization discovered Dengue virus genotype 1 as the causing pathogen, imported by an unrecognized index case, probably from the Indian subcontinent. Retrospective analysis showed this to be the first autochthonous infection of Dengue fever since the 1930’s in Europe. West Nile neuroinvasive disease (WNND), is a serious illness caused by West Nile virus and presents with one of three major clinical syndromes: meningitis, encephalitis or flaccid paralysis. In 2012 the first cases of WNND have been recorded in Croatia. In the following year three times as many cases were hospitalized. In contrast to 2012, where all patients contracted WNND in the eastern parts of Croatia, in 2013 the patients got infected in and around the City of Zagreb. Phylogenetic analysis of parts of the genome showed close relation to strains circulating in neighbouring countries. A limited molecular analysis of Aedes albopictus and ¬Culex pipiens, from various parts of Croatia, did not show any traces of human pathogenic flavi- or alphaviruses.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita

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