Naslov
In vitro and in vivo effect of natural clinoptilolite on malignant tumors

Autori
Poljak-Blaži, Marija ; Katić, Maša ; Kralj, Marijeta ; Žarković, Neven ; Marotti, Tanja ; Bošnjak, Berislav ; Šverko, Višnja ; Balog, Tihomir ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 13th International Zeolite Conference "Zeolites and Mesoporous Materials at the Dawn of the 21st Century" ; Studies in surface science and catalysis ; Vol. 135 / Galarneau, A. ; di Renzo, F. ; Fajula, F. ; Vedrine, J. - Amsterdam : Elsevier, 2001, 374-374

ISBN
978-0-444-50238-4

Skup
International Zeolite Conference (13 ; 2001)

Mjesto i datum
Montpellier, Francuska, 08.07.2001. - 13.07.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
natural clinoptilolite; tumor

Sažetak
Many biochemical processes are closely related to ion change, adsorption and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide, they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. In vitro experiments showed inhibition of tumor cell proliferation as well as MZ to be the possible scavenger of HNE. After i.p. application of MZ, the number of peritoneal macrophages was increased as well as their production of oxide anion. NO generation was totally abolished. At te same time translocationof p65 subunit of NF-kapaB in spleen cells was observed. Thus, here we report anticancer effect of MZ in vitro and immunostimulatory effect in vivo. We also propose possible mechanism of its action in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA