Naslov
In vitro and in vivo effect of natural clinoptilolite on malignant tumors

Autori
Poljak-Blaži, Marija ; Katić, Maša ; Kralj, Marijeta ; Žarković, Neven ; Marotti, Tanja ; Bošnjak, Berislav ; Šverko, Višnja ; Balog, Tihomir ; Pavelić, Krešimir

Izvornik
Studies in Surface Science and Catalysis (0167-2991) 135 (2001); 5309-5316

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
natural clinoptilolite; tumor

Sažetak
Many biochemical processes are closely related to ion change, adsorption and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide, they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. In vitro experiments showed inhibition of tumor cell proliferation as well as MZ to be the possible scavenger of HNE. After i.p. application of MZ, the number of peritoneal macrophages was increased as well as their production of oxide anion. NO generation was totally abolished. At te same time translocationof p65 subunit of NF-kapaB in spleen cells was observed. Thus, here we report anticancer effect of MZ in vitro and immunostimulatory effect in vivo. We also propose possible mechanism of its action in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA