Naslov
The concentrations of the inflammatory markers the amino-terminal portion of C-type pronatriuretic peptide and procalcitonin in canine babesiosis caused by Babesia canis

Autori
Brkljačić, Mirna ; Torti, Marin ; Pleadin, Jelka ; Mrljak, Vladimir ; Šmit, Iva ; Kiš, Ivana ; Mayer, Iva ; Crnogaj, Martina ; Matijatko, Vesna

Izvornik
Veterinarski arhiv (0372-5480) 84 (2014), 6; 575-589

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
babesiosis; dog; inflammatory marker; C-type pronatriuretic peptide; procalcitonin; outcome

Sažetak
Canine babesiosis is a multisystemic protozoan disease, considered as sepsis with a wide range of clinical signs, which can result in various outcomes, from mild to fatal. In veterinary medicine there are still no specific biomarkers for sepsis, therefore the aim of this study was to investigate markers widely used in human medicine, but poorly in veterinary medicine and never in canine babesiosis. Ninety-seven dogs were included in this study, among which 72 were diagnosed for babesiosis and 25 were healthy and used as the control group. Concentrations of procalcitonin (PCT) and the amino-terminal portion of C-type pronatriuretic peptide (NT-pCNP) were determined for each dog. There was a significant difference in PCT concentrations between the healthy and the babesiosis group before and after the antibabesial treatment, but there were no significant differences between the dogs that survived and the dogs that died. In contrast, there was no significant difference in NT-pCNP concentrations between the healthy and babesiosis groups before and after the antibabesial treatment, but there were significant differences between the dogs that survived and the dogs that died. It may be concluded that as in human medicine, PCT is most probably a good marker for both detection and grading of SIRS complications developed only in bacterial induced systemic infections, whereas NT-pCNP can be considered a good prognostic pro-inflammatory marker of outcome in canine babesiosis.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA