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Pregled bibliografske jedinice broj: 746299

COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE


Novokmet, Mislav; Pučić, Maja; Pinto, Sofia; Vlahoviček, Kristijan; Gornik, Olga; Lauc, Gordan
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE // 10th Congress of the Croatian Society of Biochemistry and Molecular Biology
Opatija, Hrvatska, 2010. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 746299 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE

Autori
Novokmet, Mislav ; Pučić, Maja ; Pinto, Sofia ; Vlahoviček, Kristijan ; Gornik, Olga ; Lauc, Gordan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
10th Congress of the Croatian Society of Biochemistry and Molecular Biology

Mjesto i datum
Opatija, Hrvatska, 15.09.2010. - 18.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glycan analysis /human plasma glycome/ N-glycans /protein glycosylation

Sažetak
After performing hydrophilic interaction and weak anion exchange high-performance liquid chromatography to analyze N-glycans in the plasma of 1991 people, we identified several individuals that differed significantly from the “normal” profile of N-glycans. By performing consensus scoring of pairwise distances between vectors containing measured glycan values, we formed six groups of individuals with specific glyco-phenotypes. Some aberrations from the normal plasma protein patterns were found to be associated with clinical conditions (such as renal problems in people with increased monosialylated biantennary glycans, A2G2S1), while other substantial changes inN-glycan structure, such as the near complete absence of neutral glycans or antennary fucosylated tri- and tetraantennary glycans, were not associated with any observed adverse health outcomes. These results demonstrate the existence of specific altered glyco-phenotypes in some individuals and indicate that in some cases they might represent risk factors for the development of specific diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
GENOS d.o.o.


Citiraj ovu publikaciju:

Novokmet, Mislav; Pučić, Maja; Pinto, Sofia; Vlahoviček, Kristijan; Gornik, Olga; Lauc, Gordan
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE // 10th Congress of the Croatian Society of Biochemistry and Molecular Biology
Opatija, Hrvatska, 2010. (poster, međunarodna recenzija, sažetak, znanstveni)
Novokmet, M., Pučić, M., Pinto, S., Vlahoviček, K., Gornik, O. & Lauc, G. (2010) COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE. U: 10th Congress of the Croatian Society of Biochemistry and Molecular Biology.
@article{article, author = {Novokmet, Mislav and Pu\v{c}i\'{c}, Maja and Pinto, Sofia and Vlahovi\v{c}ek, Kristijan and Gornik, Olga and Lauc, Gordan}, year = {2010}, keywords = {glycan analysis /human plasma glycome/ N-glycans /protein glycosylation}, title = {COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE}, keyword = {glycan analysis /human plasma glycome/ N-glycans /protein glycosylation}, publisherplace = {Opatija, Hrvatska} }
@article{article, author = {Novokmet, Mislav and Pu\v{c}i\'{c}, Maja and Pinto, Sofia and Vlahovi\v{c}ek, Kristijan and Gornik, Olga and Lauc, Gordan}, year = {2010}, keywords = {glycan analysis /human plasma glycome/ N-glycans /protein glycosylation}, title = {COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE}, keyword = {glycan analysis /human plasma glycome/ N-glycans /protein glycosylation}, publisherplace = {Opatija, Hrvatska} }




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