Pregled bibliografske jedinice broj: 746299
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE // 10th Congress of the Croatian Society of Biochemistry and Molecular Biology
Opatija, Hrvatska, 2010. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 746299 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
COMMON ABERRATION FROM THE NORMAL HUMAN PLASMA N-GLYCAN PROFILE
Autori
Novokmet, Mislav ; Pučić, Maja ; Pinto, Sofia ; Vlahoviček, Kristijan ; Gornik, Olga ; Lauc, Gordan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
10th Congress of the Croatian Society of Biochemistry and Molecular Biology
Mjesto i datum
Opatija, Hrvatska, 15.09.2010. - 18.09.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
glycan analysis /human plasma glycome/ N-glycans /protein glycosylation
Sažetak
After performing hydrophilic interaction and weak anion exchange high-performance liquid chromatography to analyze N-glycans in the plasma of 1991 people, we identified several individuals that differed significantly from the “normal” profile of N-glycans. By performing consensus scoring of pairwise distances between vectors containing measured glycan values, we formed six groups of individuals with specific glyco-phenotypes. Some aberrations from the normal plasma protein patterns were found to be associated with clinical conditions (such as renal problems in people with increased monosialylated biantennary glycans, A2G2S1), while other substantial changes inN-glycan structure, such as the near complete absence of neutral glycans or antennary fucosylated tri- and tetraantennary glycans, were not associated with any observed adverse health outcomes. These results demonstrate the existence of specific altered glyco-phenotypes in some individuals and indicate that in some cases they might represent risk factors for the development of specific diseases.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
GENOS d.o.o.