Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 746136

STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA


Gornik, Olga; Knežević, Ana; Pučić, Maja; Redžić, Irma; Wagner, Jasenka; Lauc, Gordan
STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA // The Sixth ISABS Conference on human genome project based applications in Forensic Science, Anthropology and Individualized medicine
Split, Hrvatska, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 746136 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA

Autori
Gornik, Olga ; Knežević, Ana ; Pučić, Maja ; Redžić, Irma ; Wagner, Jasenka ; Lauc, Gordan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The Sixth ISABS Conference on human genome project based applications in Forensic Science, Anthropology and Individualized medicine

Mjesto i datum
Split, Hrvatska, 01.06.2009. - 05.06.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glycans; stability

Sažetak
Glycan heterogeneity was shown to be associated with numerous diseases and glycan analysis has a great diagnostic potential. Recently, we reported high biological variability of human plasma N-glycome at the level of population. The observed variations were larger than changes reported to be associated with some diseases ; thus, it was of great importance to examine the temporal constancy of human N-glycome before glycosylation changes could be routinely analyzed in diagnostic laboratories. Plasma samples were taken from 12 healthy individuals. The blood was drawn on seven occasions during 5 days. N-Linked glycans, released from plasma proteins, were separated using hydrophilic interaction high performance liquid chromatography into 16 groups (GP1-GP16) and quantified. The results showed very small variation in all glycan groups, indicating very good temporal stability of N-glycome in a single individual. Coefficients of variation from 1.6% for GP8 to 11.4% for GP1 were observed. The average coefficient of variation was 5.6%. These variations were comparable to those observed when analytical procedure was tested for its precision. Good stability of plasma N-glycome in healthy individuals implies that glycosylation is under significant genetic control. Changes observed in glycan profiles are consequence of environmental influences and physiologic responses and therefore have a significant diagnostic potential.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.


Citiraj ovu publikaciju:

Gornik, Olga; Knežević, Ana; Pučić, Maja; Redžić, Irma; Wagner, Jasenka; Lauc, Gordan
STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA // The Sixth ISABS Conference on human genome project based applications in Forensic Science, Anthropology and Individualized medicine
Split, Hrvatska, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)
Gornik, O., Knežević, A., Pučić, M., Redžić, I., Wagner, J. & Lauc, G. (2009) STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA. U: The Sixth ISABS Conference on human genome project based applications in Forensic Science, Anthropology and Individualized medicine.
@article{article, author = {Gornik, Olga and Kne\v{z}evi\'{c}, Ana and Pu\v{c}i\'{c}, Maja and Red\v{z}i\'{c}, Irma and Wagner, Jasenka and Lauc, Gordan}, year = {2009}, keywords = {glycans, stability}, title = {STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA}, keyword = {glycans, stability}, publisherplace = {Split, Hrvatska} }
@article{article, author = {Gornik, Olga and Kne\v{z}evi\'{c}, Ana and Pu\v{c}i\'{c}, Maja and Red\v{z}i\'{c}, Irma and Wagner, Jasenka and Lauc, Gordan}, year = {2009}, keywords = {glycans, stability}, title = {STABILITY OF N-GLYCAN PROFILES IN HUMAN PLASMA}, keyword = {glycans, stability}, publisherplace = {Split, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font