Naslov
Clinical and pathophisiological significance of antineutrophil autoantibodies (ANCA) in vasculitis
(Clinical and pathophysiological significance of antineutrophil autoantibodies (ANCA)in vasculitis)

Autori
Kozmar, Ana ; Malenica, Branko

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, ostalo

Knjiga
Lung in non-pulmonary and systemic disease

Urednik/ci
Peroš-Golubičić, Tatjana

Izdavač
Medicinska naklada

Grad
Zagreb

Godina
2013

Raspon stranica
367-381

ISBN
978-953-176-643-2

Ključne riječi
ANCA, PR3, MPO, primary small vessel vasculitis
(ANCA, PR3, MPO, primary small vessel vasculitides)

Sažetak
Antineutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 or myeloperoxidase are strongly associated with ANCA-associated vasculitides-Wegener s granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome. They produce either perinuclear or cytoplasmic fluorescence pattern on ethanol-fixed neutrophils by indirect immunofluorescence. ANCA are useful tools for diagnosing and monitoring primary small vessel vasculitides. ANCA testing is a highly sensitive and specific test for making a diagnosis of Wegener s granulomatosis, microscopic polyangiitis or Curg-Strauss syndrome. In these patients, ANCA titers are related to disease activity and a rise in titer may precede a clinical relapse. Several findings indicate that ANCA and their target antigens may be implicated in the pathogenesis of primary small vessel vasculitides. This evidence comes from clinical observations, in vitro and in vivo experiments.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA