Pregled bibliografske jedinice broj: 742626
The analysis of enzymes matrix metalloproteinases- 2 and 9 in atherosclerosis
The analysis of enzymes matrix metalloproteinases- 2 and 9 in atherosclerosis // /
Malinska, Hrvatska, 2014. str. /-/ (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 742626 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The analysis of enzymes matrix metalloproteinases-
2 and 9 in atherosclerosis
Autori
Mrakovčić-Šutić, I ; Bulog, A ; Mićovi㏠V ; Lekić, A ; Gobić, D ; Kovačević, M
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
6th Internartional Symposium of Clinical and Applied Anatomy
Mjesto i datum
Malinska, Hrvatska, 26.06.2014. - 29.06.2014
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
atherosclerosis ; enzymes matrix metalloproteinases-2 and 9
Sažetak
The members of the matrix metalloproteinase (MMP) family play a crucial role in angiogenesis and vascular remodeling and are involved in the pathogenesis of vascular diseases such as atherosclerosis, varicose veins, hypertension, abdominal aortic aneurysm, preeclampsia, etc. Alterations in vascular tone are usually a result of changeable endothelial cell function, as well as increasing activity of neurohormonal stimuli or altered sensitivity of vascular smooth muscle. Chronic changes in vascular function lead to structural changes in the blood vessel architecture. The aim of our study was to examine the values of enzyme matrix metalloproteinase-9 in urine in patients with atherosclerosis of carotid arteries, undergoing surgery, and compare to controls (healthy volunteers). Patients and methods: we analyzed 40 patients with atherosclerosis who were undergoing the surgical procedure. The method of enzyme immunoassay (ELISA) was used to determine enzymes expression of matrix metalloproteinase-2 and 9 (MMP-2 and 9). Statistical data were Calculated using computer program Statistica 7.1. Results: The patients with atherosclerosis had a statistically significantly increased level of MMP-2 and 9 in the urine in comparison with healthy volunteers. Conclusion: Our data has showed a large increase in the enzyme MMP-2 and 9 in the urine of atherosclerotic patients, which can be an easy marker for the monitoring of the development of atherosclerosis.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
062-0620096-0094 - Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti (Mrakovčić-Šutić, Ines, MZOS ) ( CroRIS)
062-0621341-0308 - Odgovor ljudi i morskih organizama na ekološko zagađenje u Kvarnerskom zaljevu (Mićović, Vladimir, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Andrica Lekić
(autor)
Aleksandar Bulog
(autor)
Miljenko Kovačević
(autor)
David Gobić
(autor)
Ines Mrakovčić-Šutić
(autor)