Pregled bibliografske jedinice broj: 742597
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia. // Archives of virology, 160 (2015), 1; 297-304 doi:10.1007/s00705-014-2283-0 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 742597 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.
Autori
Perić, Magdalena ; Bošnjak, Zinka ; Šarkanj, Bojan ; Barbić, Jerko ; Antolović-Požgain, Arlen ; Ružman, Nataša ; Roksandić-Križan, Ivana ; Vuković, Dubravka
Izvornik
Archives of virology (0304-8608) 160
(2015), 1;
297-304
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
hepatitis C virus; HCV genotype; TLR2; TLR4; gene polymorphism; antiviral therapy
Sažetak
Chronic infection with hepatitis C virus (HCV) is caused by an inadequate immune response. Experimental data suggest that the impaired activation of Toll-like receptors (TLRs) 2 and 4 contributes to chronic infection. We assessed the distribution of three single-nucleotide polymorphisms (SNPs) in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly/Thr399Ile) genes in individuals from north-east Croatia and their effect on the outcome of antiviral therapy. The study consisted of 60 chronically infected patients and 40 healthy subjects. TLR polymorphisms were determined by the PCR-based melting curve analysis. HCV genotyping was performed using the Linear Array Hepatitis C Virus Genotyping Test. Thirty-three patients were treated with standard interferon and ribavirin therapy, and their viral load was evaluated at weeks 28 and 53 after the beginning of therapy. The majority of chronic infections were caused by genotype 1 (77%), followed by genotypes 3 (15%) and 4 (7%). Patients with genotype 1 had higher viral loads than patients infected with other genotypes (P = 0.0428). Healthy individuals and patients with chronic infection had similar frequencies of TLR2-Arg753Gln and TLR4-Asp299Gly/Thr399Ile SNPs. Heterozygous and homozygous TLR4- Asp299Gly/Thr399Ile polymorphisms correlated with higher viral loads and delayed responses to antiviral therapy. We have provided the first evidence that TLR4 polymorphisms influence the success of antiviral therapy in our region. This suggests that therapeutic strategies should be adjusted not only according to HCV genotype but also to individual TLR polymorphism(s).
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Barbić, Jerko, MZOS ) ( CroRIS)
Ustanove:
Prehrambeno-tehnološki fakultet, Osijek,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Medicinski fakultet, Osijek
Profili:
Bojan Šarkanj
(autor)
Zinka Bošnjak
(autor)
Magdalena Perić
(autor)
Jerko Barbić
(autor)
Arlen Antolović-Požgain
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- AGRICOLA
- ASFA: Aquatic Science and Fisheries Abstracts
- BIOSIS Previews (Biological Abstracts)
- CAB Abstracts
- FSTA: Food Science and Technology Abstracts
- MEDLINE