Naslov
Effect of adamantyl compounds on dynamics of spin labelled multilamellar liposomes

Autori
Mirosavljević, Krunoslav ; Matković, Marija ; Milnarić-Majerski, Kata ; Nothig-Laslo, Vesna

Izvornik
Croatica chemica acta (0011-1643) 87 (2014), 3; 249-253

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adamantyl compounds ; drug transport ; drug interactions ; physicochemical properties ; spin labelling ; ESR ; spectroscopy ; liposomes ; phospholipids

Sažetak
Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride (compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dynamics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggested that both adamantyl compounds influenced molecular motions in the interfacial region of the liposome. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamellar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydrophobic core as well.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA