Pregled bibliografske jedinice broj: 740993
QUERCETIN VS CHRYSIN: EFFECT ON LIVER HISTOPATHOLOGY IN DIABETIC MICE
QUERCETIN VS CHRYSIN: EFFECT ON LIVER HISTOPATHOLOGY IN DIABETIC MICE // Drugi simpozij Hrvatskog društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem “Pokusne životinje u znanstvenim istraživanjima”
Zagreb, 2014. str. 90-91 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 740993 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
QUERCETIN VS CHRYSIN: EFFECT ON LIVER HISTOPATHOLOGY IN DIABETIC MICE
Autori
Sirovina, Damir ; Oršolić, Nada ; Zovko Končić, Marijana ; Kovačević, Goran ; Benković, Vesna ; Gregorović, Gordana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Drugi simpozij Hrvatskog društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem “Pokusne životinje u znanstvenim istraživanjima”
/ - Zagreb, 2014, 90-91
Skup
Pokusne životinje u znanstvenim istraživanjima
Mjesto i datum
Zagreb, Hrvatska, 10.10.2014
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
diabetes; quercetin; chrysin; lipid peroxidation; histopathology
Sažetak
The antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro were studied and compared with their effects on lipid peroxidation and histopathological changes in liver of diabetic mice. Diabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg-1). Two days after alloxan injection, flavonoids preparations (50 mg kg-1 per day) were given intraperitoneally for 7 days in diabetic mice. Antioxidant activity was analyzed as DPPH free radical scavenging activity, reducing power and the capability to chelate iron (II) ions. In vitro chrysin demonstrated notable antiradical activity albeit much lower than quercetin which was an extremely effective radical scavenger. The reducing power of both flavonoids was notable but lower than the activity of ascorbic acid. Both flavonoids demonstrated notable chelating ability towards ferrous ion, chrysin being more active of the two. The lipid peroxidation was evaluated by measuring the MDA production using the 2-thiobarbituric acid TBA test. Administration of quercetin and chrysin to diabetic mice resulted in a significant decrease of lipid peroxidation level in liver tissue. Treatment of diabetic mice with flavonoids solutions results in decreased number of vacuolated cells and degree of vacuolization of the liver tissue. Quercetin and chrysin have beneficial effects on liver histopathology in diabetic mice, according to their antioxidant capacity in vitro. The protective role of flavonoids against the ROS induced damages in diabetic mice gives a hope that they may exert similar protective action in humans.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Vesna Benković
(autor)
Damir Sirovina
(autor)
Marijana Zovko Končić
(autor)
Goran Kovačević
(autor)
Gordana Gregorović
(autor)
Nada Oršolić
(autor)