Naslov
The 49a,f Haplotype 11 is a New Marker of the EU19 Lineage that Traces Migrations from Northern Regions of the Black Sea

Autori
Passarino, Giuseppe ; Semino, Ornella ; Magri, Chiara ; Al-Zahery, Nadia ; Benuzzi, Giorgia ; Quintana-Murci, Luis ; Anđelinović, Šimun ; Bulić-Jakuš, Floriana ; Liu, Aiping ; Arslan, Ahmet ; Santachiara-Benerecetti, Silvana

Izvornik
Human Immunology 62 (2001); 922-932

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Y-chromosome polymorphisms; East Europe; Ukraine; migrations

Sažetak
Previous studies on human Y-chromosome polymorphisms in the European population highlighted the high frequency of the 49a,f /TaqI haplotype 11 and of the Eu19 (M17) lineage in Eastern Europe. To better understand the origin and the evolution of the Eu19, and its relationship with 49a,f Ht11, this study surveyed 2.235 individuals (mainly from Europe and the Middle East) for the 49a,f Ht11 and for many biallelic markers defining the Eu19 lineage. As previously described, the highest frequency of Eu19 was found in Eastern Europe. All the Eu19 Y-chromosomes turned out to be 49a,f Ht11 or its derivatives, the distribution of which suggests that the Eu19/49a,f Ht11 emerged in Ukraine, probably in Palaeolitic population. Thereafter, the spread of this lineage toward Europe, Asia and India occured at different waves over a few thousand years. At present this seems to indicate the influence of the Ukraine Palaeolithic groups in the gene pool of modern populations. For the first time it is possible to make inferences about the evolution of some haplotypes of the 49a,f system. In spite of its unknown molecular base, this is one of the first most informative polymorphisms of the Y chromosome.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA