Pregled bibliografske jedinice broj: 736981
A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure
A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure // Organic & biomolecular chemistry, 13 (2015), 1629-1633 doi:10.1039/c4ob02169j (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 736981 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure
Autori
Radić Stojković, Marijana ; Piotrowski, Patryciusz ; Schmuck, Carsten ; Piantanida, Ivo
Izvornik
Organic & biomolecular chemistry (1477-0520) 13
(2015);
1629-1633
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
guanidiniocarbonyl-pyrrole; pyrene; DNA/RNA binding; fluorescence; CD
Sažetak
A novel pyrene-guanidiniocarbonyl-pyrrole dye, characterised by a short, rigid linker between the two chromophores, interacts strongly with ds-DNA but only negligibly with ds-RNA. At neutral conditions the dye shows strong selectivity toward AT-DNA (in respect to GC-DNA). Binding is accompanied by a specific ICD band at 350 nm and fluorescence quenching for all DNA/RNA studied. At pH 5 the affinity of the dye is reversed, now favouring GC-DNA over AT-DNA. A strong emission increase for AT-DNA is observed but quenching for GC-DNA.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( CroRIS)
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
