Naslov
Modulation of oxidative stress, vascular function and inflammation by AT1 receptor blockade in patients with essential hypertension

Autori
Mihalj, Martina ; Tadžić, Refmir ; Včev, Aleksandar ; Ručević, Silvija ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
Third International Symposium on Hypertension - Translational Medicine in Hypertension and joung Investigator Conference

Mjesto i datum
Osijek, Hrvatska, 28.11.2014. - 30.11.2014

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hipertenzija; oxidativni stres; AT1 receptori
(Hypertension; oxidative stress; AT1 receptors)

Sažetak
The aim of this study was to investigate the effects of AT1 blockade on the oxidative stress marker 8-iso-prostaglendin F2-alpha (8iPGF2α), vascular function and inflammation in patients with essential hypertension. An additional aim was to test whether supplementation of antioxidants can further decrease blood pressure (BP) by reducing the level of oxidative stress. 57 newly discovered hypertensive patients were randomly divided into two groups receiving AT1 antagonist olmesartan (10-20mg/day, N=27) or Ca-channel blocker amlodipine (5-10mg/day, N=30). Patients on amlodipine were used as a control group to specifically test the effect of AT1 blockade and to differentiate these effects from the mere blood pressure reduction. After 8 weeks of therapy patients from both groups were further subdivided according to addition of vitamin C or placebo. Serum levels of 8iPGF2α, sICAM-1, sVCAM-1, sE-selectin were measured by ELISA at the time of inclusion in the study and after 8 and 16 weeks of treatment. Vascular function was assessed by flow mediated dilatation (FMD). In both groups BP reached target values <140/90 within the first 8 weeks and it could not be further reduced by the vitamin C supplementation. 8iPGF2α levels were significantly decreased after 16 weeks of treatment in both groups. Although there was no difference in mean values between the subgroups, the size of 8iPGF2α reduction was significantly greater in patients taking vitamin C in amlodipine group. 8iPGF2α levels positively correlated to systolic (p=0.0009) and diastolic (p=0.001) BP in amlodipine group, while to only diastolic BP levels in olmesartan group (p=0.0038). There were no changes in inflammation and vascular function parameters that could be correlated to the specific action of AT1 blockade. Reduction of 8iPGF2α was not affect by the type of treatment suggesting that ROS/RNS production is a predominant result of the BP elevation. AT1 blockade correlated with lower change in 8iPGF2α levels during vitamin C supplementation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA