Pregled bibliografske jedinice broj: 736566
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition // Cytotechnology, 68 (2016), 783-794 doi:10.1007/s10616-014-9829-6 (međunarodna recenzija, članak, znanstveni)
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Naslov
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition
Autori
Madunić, Josip ; Antica, Mariastefania ; Cvjetko, Petra ; Požgaj, Lidija ; Matulić, Maja
Izvornik
Cytotechnology (0920-9069) 68
(2016);
783-794
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
urokinase plasminogen activator ; plasminogen activator inhibitor-1 ; poly(ADP-ribose)polymerase-1 ; DNA damage
Sažetak
The urokinase plasminogen activator (uPA) system is a complex regulator of extracellular proteolysis which is involved in various physiological and pathological processes. The major components of this system are the serine protease uPA, two inhibitors PAI-1 and PAI-2, and the receptor uPAR. It has been previously shown by several groups that the uPA system has an important role in cancer progression and therefore its possible prognostic and therapeutic value has been evaluated. The aim of this study is to tackle the role of poly(ADP-ribosyl)ation in the induction of uPA activity in a glioblastoma cell line, A1235. This cell line is sensitive to alkylation damage and is a model for drug treatment. The components of the uPA system and the level of DNA damage were analyzed after alkylation agent treatment in combination with poly(ADP- ribose)polymerase-1 (PARP-1) inhibition. Here we show that the increase in uPA activity results from the net balance change between uPA and its inhibitor on mRNA level. Further, PARP- 1 inhibition exerts its influence on uPA activity through DNA damage increase. Involvement of several signaling pathways, as well as cell specific regulation influencing the uPA system is discussed
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Antica, Mariastefania, MZOS ) ( CroRIS)
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Matulić, Maja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Lidija Pribolšan
(autor)
Petra Cvjetko
(autor)
Maja Matulić
(autor)
Josip Madunić
(autor)
Mariastefania Antica
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus