Naslov
Comparison between Intraperitoneal and Oral Methylphenidate Administration : A Microdialysis and Locomotor Activity Study

Autori
Gerasimov, Madina R. ; Franceschi, Maja ; Volkow, Nora D. ; Gifford, Andrew ; Gatley, Samuel J. ; Marsteller, Douglas ; Molina, Patricia E. ; Dewey, Stephen L.

Izvornik
The Journal of pharmacology and experimental therapeutics (0022-3565) 295 (2000), 1; 51-57

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
methylphenidate; dopamine; local cerebral glucose utilization; nucleus accumbens

Sažetak
The therapeutic and stimulant properties of methylphenidate (MP), a drug commonly prescribed for the treatment of attention deficit hyperactivity disorder, have been attributed to increases in synaptic dopamine (DA) concentrations resulting from the blockade of DA transporters. In addition to obvious difficulties inherent in any interspecies comparison, interpretation of preclinical studies done with MP is further complicated by different routes of administration in animals (i.v. and i.p.) compared with humans (oral). This study shows that relatively low doses of MP (2 mg i.p. and 5 mg intragastric) significantly increase extracellular DA and locomotor activity and indicates that the differences in the neurochemical and behavioral effects of MP between the intragastric ant the i.p. routes are due to central drug bioavailability.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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