Naslov
Differential innate immune resistance of ovarian corpora lutea and follicles to cytomegalovirus infection

Autori
Tomac, Jelena ; Juranić Lisnić, Vanda ; Linić, Ida ; Trsan, Tihana ; Golemac, Mijo ; Lars Dölken, Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Croatian Immunological Society, 2014 Annual meeting / - Rijeka : Hirvatsko imunološko društvo, 2014

Skup
Croatian Immunological Society, 2014 Annual meeting

Mjesto i datum
Krk, Hrvatska, 17.10.2014. - 18.10.2014

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV ovary
(MCMV; Ovary)

Sažetak
Human cytomegalovirus (HCMV) is a major viral cause of morbidity following congenital infection and a cause of miscarriage during early pregnancy. Employing the murine cytomegalovirus (MCMV) model, we show early pregnancy loss to be due to an exquisite, overwhelming infection of ovarian corpora lutea (CL). Excessive infection of CL granulosa cells, the main producers of progesterone during early pregnancy, was accompanied by a detrimental regulation of key genes involved in the synthesis and degradation of serum progesterone levels and substantial pregnancy loss. In contrast to CL, ovarian follicles are completely resistant to MCMV infection even in highly immunocompromised hosts. Here we have characterized and discussed the mechanisms of differential innate resistance of CL and ovarian follicles to MCMV infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA