Pregled bibliografske jedinice broj: 735493
Management of Cushing’s disease: a single-center experience
Management of Cushing’s disease: a single-center experience // Endocrine (Basingstoke), 51 (2016), 3; 517-523 doi:10.1007/s12020-015-0695-6 (recenziran, članak, znanstveni)
CROSBI ID: 735493 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Management of Cushing’s disease: a single-center experience
Autori
Solak, Mirsala ; Kraljević, Ivana ; Dušek, Tina ; Melada, Ante ; Marjanović Kavanagh, Marcel ; Peterković, Vjerislav ; Ozretić, David ; Kaštelan, Darko
Izvornik
Endocrine (Basingstoke) (1355-008X) 51
(2016), 3;
517-523
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cushing's disease ; pituitary adenoma ; transsphenoidal surgery ; remission ; comorbidity
Sažetak
The purpose of this study was to review therapeutic outcomes and comorbidities of patients with Cushing's disease (CD) in a single center. We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014 (27 females and 6 males, median age 38 years, range 18-71 years). The diagnosis of Cushing's syndrome was established on the basis of the patient's history, characteristic clinical features, and laboratory data including an elevated 24-h urinary free cortisol level, lack of serum cortisol suppression after dexamethasone suppression tests and an elevated midnight cortisol level. In 28/33 patients, the tumor was visualized on MR of the sellar region, while in 5 it was diagnosed using an inferior petrosal sinus sampling. Out of the 33 patients, 10 had macroadenoma and the remaining 23 had microadenoma. Twenty-one patients (63.6 %) had hypertension, 17 (51.5 %) dyslipidemia, and 7 (21.2 %) had type 2 diabetes or impaired glucose tolerance. The median follow-up period was 28 months. Remission after transsphenoidal surgery was achieved in 78.8 % of patients, while 7 patients failed to achieve disease remission. Those patients were treated with second-line treatment modalities (second operation, radiotherapy, bilateral adrenalectomy, and/or ketoconazole). One patient rejected all the treatment modalities after surgery. Cumulative remission after all the treatment modalities was achieved in 87.9 % patients. Patients with Cushing's disease should be managed in centers with much experience due to high patient load. In our Center, the remission of the disease has been achieved in 78.8 % of the patients following transsphenoidal surgery. Multimodal treatment which included radiotherapy and medical treatment led to biochemical remission of the disease in 87.9 % of patients.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinički bolnički centar Zagreb
Profili:
Tina Dušek
(autor)
David Ozretić
(autor)
Ivana Kraljević
(autor)
Vjerislav Peterković
(autor)
Ante Melada
(autor)
Darko Kaštelan
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE