Naslov
Valproate-acid-induced cutaneous leukocytoclastic vasculitis

Autori
Lasić, Davor ; Ivanišević, Ranka ; Uglešić, Boran ; Cvitanović Žuljan, Marija ; Glučina, Dubravka ; Hlevnjak, Ivana.

Izvornik
Psychiatria Danubina (0353-5053) 24 (2012), 2; 215-218

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Valproična kiselina; kožni leukocitoklastični vaskulitis
(Valproate-acid; cutaneous leukocytoclastic vasculitis)

Sažetak
Valproate-induced vasculitis is seen as an adverse drug reaction in ratio that is less than 1/1000. Leukocytoclastic vasculitis can also occur internally. The cutaneous features of leukocytoclastic vasculitis are highly variable and may change rapidly. Valproic acid (VPA) is a chemical compound and an acid that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, atypical depression with hypersomnia. A 35-year-old woman presented with purpuric papules on her lower extremities was admitted to the Department of Dermatology and Venerology, University Hospital Centre Split. Clinical recognition of drug-induced vasculitic is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA