Naslov
Come-back of phenanthridine and phenanthridinium derivatives in 21st century

Autori
Tumir, Lidija-Marija ; Radić Stojković, Marijana ; Piantanida, Ivo

Izvornik
Beilstein journal of organic chemistry (1860-5397) 10 (2014); 2930-2954

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
phenanthridine; phenanthridinium; organic synthesis; ds-DNA and ds-RNA binding; intercalation; minor groove binding

Sažetak
Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding ; attracting attention about time of DNA structure discovery (1960ies), early recognized as a symbol of DNA intercalative binding, for many decades applied as gold-standard DNA- and RNA-fluorescent markers (ethidium bromide), probes for cell viability (propidium iodide), but also “ill-famed” for various toxic (genotoxic) and mutagenic effects. After two decades of low interest, the discovery of phenanthridine alkaloids and new studies of antiparasitic/antitumour properties of phenanthridine derivatives resulted in the strong increase of the scientific interest about the turn of this century. Here are summarized phenanthridine-related advances in the 21st century (2000-present period) with emphasis on the supramolecular interactions and bioorganic chemistry, as well as novel or improved synthetic approaches.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA