Naslov
Hair silver median derivates for the assessment of the environmental silver exposure, overexposure, and toxicity

Autori
Momčilović, Berislav ; Prejac, Juraj ; Višnjević, Vjeran ; Mimica, Ninoslav ; Skalny, Anatoly V. ; Morović, Sandra ; Čelebić, Asja

Izvornik
Trace elements in medicine (1607-9957) 13 (2012), 3; 27-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hair silver ; exposure ; overexposure ; toxicity ; median derivates ; logistic fit

Sažetak
Silver was analyzed in the hair of 213 occupationally non- exposed subjects (87 men, 126 women) with the inductively coupled plasma mass spectrometry (ICP MS). Median hair Ag con- centration was 0.070 jlig/g for both sexes combined ; but women's hair have more Ag than that of men (p < 0.05, Chi square test). The hair silver below 0.010 (ig/g and 0.015 [ig/g for men and women, re-spectively, appeared to be toxicologically irrelevant, and to only reflect random silver distribution between the other biochemical compartments of the human body. Above that concentration level hair silver con- centration diverges upward, first for men and then for women and rose rapidly in a parallel type biological assay pattern, indicating the physiological saturation mechanism. These t\vo distinct parallel saturation curves for men and women would converge back to the common sigmoid overexposure plateau at 0.210 jug/g and 0.358 jug/g for men and women, re-spectively. Combined with the medical history, our data indicate the hair silver of 2.00 jug/g to reflect clinical sub toxicity, and its concentrations above 4.00 fig/g an overt neurotoxicity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Sažetak i na ruskom jeziku.

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