Naslov
The relevance of animal bioassays in assessing human health hazards related to occupational and ambiental exposures

Autori
Trošić, Ivančica ; Mataušić-Pišl, Mirjana ; Brumen, Vlatka ; Radalj, Željko ; Prlić, Ivica ; Cerovac, Hrvoje

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Pokusni modeli u biomedicini

Urednik/ci
Radačić, Marko ; Bašić, Ivan ; Eljuga, Damir

Izdavač
Medicinska naklada

Grad
Zagreb

Godina
2000

Raspon stranica
245-248

ISBN
953-176-108-6

Ključne riječi
animal bioassay, human health hazards, occupational and ambiental exposure, BAL

Sažetak
When studying the course and ethiopathological mechanisms underlying human lung disorders caused by external factors, it is extremly important to extend the investigations by using an experimental animal model. The advantage of such a model is that one can precisely design the experiment, keep the relevant parameters under a strict control and imitate the pathologic conditions to be studied as well as possible, opposite to a lot of well-known mostly ethic limits appering during the course of a human study. A bronchoalveolar lavage (BAL) is a useful toxicological modality for gaining access to the constituents of the lower respiratory tract. Analyses of both soluble and insoluble BAL-fluid contents are now increasingly being used to monitor the course of lung disorders. The use of an appropriate animal instillation model provides an insight into the kinetics of material in between free lung cells and lung compartments. The BAL-assay following intratracheal instillation of an experimental animal has proven to be a useful and rapid technique for the detection of lung injury caused by toxicants given.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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