Naslov
Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis.

Autori
Dolic, Kresimir ; Marr, Karen ; Valnarov, Vesela ; Dwyer, Michael Carl, Ellen ; Hagemeier, Jesper ; Kennedy, Cheryl ; Brooks, Christina ; Kilanowski, Colleen ; Hunt, Kristin ; Hojnacki, David ; Weinstock-Guttman, Bianca ; Zivadinov, Robert

Izvornik
Functional neurology (0393-5264) 26 (2011), 4; 205-214

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CCSVI ; Doppler sonography ; healthy controls ; MR venography ; multiple sclerosis ; reproducibility ; specificity

Sažetak
The aim of this study was to investigate whether a combination of Doppler sonography (DS) and magnetic resonance venography (MRV) on 3T MRI increases specificity for detection of chronic cerebrospinal venous insufficiency (CCSVI) in 171 (113 relapsing-remitting, 47 secondary- progressive, 11 primary progressive) patients with multiple sclerosis (MS) and 79 age- and sex matched healthy controls (HCs). One hundred ten (64.3%) MS patients and 30 (38%) HCs presented ≥2 venous hemodynamic CCSVI criteria (p<.0001). Both DS and MRV showed relatively high specificity but lower sensitivity for determining a CCSVI diagnosis in patients with MS vs HCs and between MS subgroups. In MS patients this diagnostic specificity increased to over 90% by combining internal jugular vein and vertebral vein abnormal DS and MRV findings, reflux in deep cerebral veins and MRV findings of >1 collateral veins. This study suggests that a multimodal non-invasive approach (DS and MRV) increases the specificity for a diagnosis of CCSVI in patients with MS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA