Naslov
Beneficial Effect of Nifedipine on Testicular Torsion-detorsion Injury in Rats

Autori
Meštrović, Jakov ; Drmić-Hofman, Irena ; Pogorelić, Zenon ; Vilović, Katarina ; Šupe-Domić, Daniela ; Šešelja-Perišin, Ana ; Čapkun, Vesna

Izvornik
Urology (0090-4295) 84 (2014), 5; 1194-1198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nifedipine; Testicular torsion-detorsion; Rat

Sažetak
Objective was to investigate the effect of nifedipine on testicular torsion-detorsion injury. Twenty-four adult male Sprague-Dawley rats were randomly divided into 3 groups, each containing 8 rats. Rats in the control group underwent a sham operation of the left testis. In the torsion-detorsion (T/D) group, the left testis was twisted at 720
for 3 hours. After 3 hours of reperfusion, at the end of the experiment, the testes were removed. Rats in the treatment group received the same surgical procedure as the T/D group, but nifedipine was administered intraperitoneally (100 mg/kg) 30 minutes before the time of detorsion. Unilateral testicular torsion-detorsion caused a significant increase in the malondialdehyde level and apoptosis and caused significant decreases in superoxide dismutase and glutathione peroxidase activities in ipsilateral testes. The rats treated with nifedipine had a significant decrease in malondialdehyde level and apoptosis and had significant increases in superoxide dismutase and glutathione peroxidase activities in ipsilateral testes compared with those of the T/D group. These results suggest that biochemical and histological torsion-detorsion injury occurs in the ipsilateral testes after a 3-hour torsion and 3-hour detorsion and that administration of nifedipine before detorsion prevents ischemia/reperfusion cellular damage in the testicular tissue.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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