Naslov
Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL- cholesterol

Autori
Vrca Bacic, Vesna ; Mayer L, Skreb F, Rahelić, Dario ; Marušić, Srećko

Izvornik
Acta pharmaceutica (1330-0075) 62 (2012), 1; 115-122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Graves' disease; antioxidants; cholesterol

Sažetak
The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL- cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL- cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencement of therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.

Izvorni jezik
Engleski

POVEZANOST RADA