Naslov
A New Route to Substituted N-hydroxyurea Derivatives

Autori
Jadrijević-Mladar Takač, Milena ; Butula, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts, 6th European Congress on Pharmaceutical Sciences, EUFEPS 2000, European Journal of Pharmaceutical Sciences, 11, Supplement 1 (2000)pp. S1-S135 (September 2000) / Linden, H. Hans - Oxford : Elsevier, 2000, S111-S112

Skup
6th European Congress on Pharmaceutical Sciences, EUFEPS 2000

Mjesto i datum
Budimpešta, Mađarska, 16.02.2003. - 19.02.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
N-Hydroxyura; Synthesis; Benzotriazole; 1; 3-5-Tribenzyloxy-biuret; 1-(N-benzyloxycarbamoylbenzotriazole; 1; 3; 5-Triazine-2; 4; 5(1H; 3H; 5H)-triones

Sažetak
The reaction of (1, Bz = benzyl) with fosgene (i) gave 1, 3, 5-(tribenzyloxy)biuret (2), whereas with BtCOCl (Bt = benzotriazolyl) (ii) gave 1-(N-benzyloxy)carbamoylbenzotriazole (5). Compounds 2 and 5 were reduced to their corresponding hydroxyl derivatives 3 and 6 (iii). The 5 and 6 were melted in presence of imidazole to afford 1, 3, 5-triazine-2, 4, 6(1H, 3H, 5H)-triones 7, X = -CON(OBz)CO-, and 8, Y = -CON(OH)CO- (iv). Scheme. Compounds 5, 6 or 7 in the reaction with ChNH2 (Ch = cyclohexyl) gave O- and/or N-substituted N-hydroxyureas 9 and 10 (v), whereas 8, due to its acidic properties, rather form cyclohexylamine salt.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

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