Pregled bibliografske jedinice broj: 731381
Acetylcholinesterase inhibitory effects of the essential oil of <i>Nigella sativa</i> L. seeds and its selected components
Acetylcholinesterase inhibitory effects of the essential oil of Nigella sativa L. seeds and its selected components // 13th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY, Book of Abstracts / Šubarić, Drago (ur.).
Osijek, 2010. str. 11-11 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 731381 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Acetylcholinesterase inhibitory effects of the essential oil of <i>Nigella sativa</i> L. seeds and its selected components
Autori
Burčul, Franko ; Carev, Ivana ; Jukić, Mila ; Politeo, Olivera ; Mlioš, Mladen ; Dražić, Antonia
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
13<sup>th</sup> Ružička days TODAY SCIENCE – TOMORROW INDUSTRY, Book of Abstracts
/ Šubarić, Drago - Osijek, 2010, 11-11
ISBN
978-953-6894-40-6
Skup
13<sup>th</sup> Ružička days TODAY SCIENCE – TOMORROW INDUSTRY
Mjesto i datum
Osijek, Hrvatska, 16.09.2010. - 17.09.2010
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Acetylcholinesterase; Nigella sativa; essential oils; carvacrol; thymoquinone
Sažetak
Alzheimer’s disease (AD) is the most common progressive form of dementia exhibited as progressive loss of memory and reduction of crucial neurotransmitter acetylcholine. Increase of acetylcholine can be achieved by inhibition of its metabolic enzyme acetylcholinesterase (AChE). AChE inhibitors are still the best available pharmacotherapy for AD patients. Plants are potential source of bioactive compounds and offer a promising strategy for the treatment of neurological disorders such as AD. The aim of this study is to isolate essential oil from <i>Nigella Sativa</i> L. seeds, determine its chemical composition, identify main components and investigate AChE inhibition of both essential oil and its components. Inhibitory activity of essential oil and some of its components were evaluated using simple colorimetric assay based on Ellman’s method. Kinetic studies were also performed for selected compounds and kinetic parameters were determined. As main constituents of the essential oil thymoquinone, <i>p</i>-cymene, isolongifolene, <i>α</i>-thujene and carvacrol were identified. The results of the Ellman assay showed that carvacrol was the strongest inhibitor, followed by <i>p</i>-cymene, thymoquinone and last essential oil. Further research should be addressed to indigenous plant <i>Nigella damascena</i> L. and compare it to <i>Nigella sativa</i> L. in all aspects.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
011-2160547-1330 - Antioksidacijski sastojci i inhibitori kolinesteraza iz aromatičnog bilja (Miloš, Mladen, MZOS ) ( CroRIS)
Ustanove:
Kemijsko-tehnološki fakultet, Split
