Naslov
Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52–Variant Lineages

Autori
Zhang, Chuqing ; Park, Jong-Sup ; Grce, Magdalena ; Hibbitts, Samantha ; Palefsky, Joel M ; Konno, Ryo ; Smith-McCune, Karen K ; Giovannelli, Lucia ; Chu, Tang-Yuan ; Picconi, María Alejandra ; Piña-Sánchez, Patricia ; Settheetham-Ishida, Wannapa ; Coutlée, Francois ; De Marco, Federico ; Woo, Yin-Ling ; Ho, Wendy C. S ; Wong, Martin C. S ; Chirenje, Mike Z ; Magure, Tsitsi ; Moscicki, Anna-Barbara ; Sabol, Ivan ; Fiander, Alison N ; Chen, Zigui ; Chan, Martin C. W ; Cheung, Tak-Hong ; Burk, Robert D ; Chan, Paul K. S.

Izvornik
The Journal of infectious diseases (0022-1899) 210 (2014), 10; 1600-1604

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HPV ; cervical cancer ; phylogeny ; oncogenic risk ; Asia

Sažetak
Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%–5.5% ; Pcorrected < .001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name “Asian lineage” be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA