Naslov
Effect of cyclosporine on steady-state pharmacokinetics of MPA in renal transplant recipients is not affected by the MPA formulation: analysis based on therapeutic drug monitoring data.

Autori
Trkulja, Vladimir ; Lalić, Zdenka ; Nađ-Škegro, Sandra ; Lebo, Ana ; Granić, Paula ; Lovrić, Mila ; Pasini, Josip ; Božina, Nada

Izvornik
Therapeutic drug monitoring (0163-4356) 36 (2014), 4; 456-464

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mycophenolate mofetil; enteric-coated mycophenolate sodium; cyclosporine; tacrolimus; renal transplant patients; therapeutic drug monitoring

Sažetak
Two oral mycophenolic acid (MPA) formulations, immediate-release mycophenolate mofetil and enteric-coated mycophenolate sodium, have been shown to differ regarding some drug-drug interactions. The aim was to assess whether the effects of cyclosporine (CsA) on steady-state pharmacokinetics (PK) of MPA in renal transplant patients were affected by MPA formulation. A prospective, stratified observational study based on therapeutic drug monitoring of MPA (6 total plasma concentrations over a 12-hour dosing interval, tau) in consecutive stable adult renal transplant recipients (n = 68). Patients treated with enteric-coated mycophenolate sodium (n = 45) or mycophenolate mofetil (n = 23) and with either CsA (micro- emulsion, n = 43) or tacrolimus (Tac) (immediate release, n = 25) were comparable regarding demographics, comorbidity, renal and liver functions, comedication, corticosteroid dose, CsA or Tac dose, and trough concentrations. Based on dose-normalized MPA concentrations and with adjustment for age, sex, body mass index, estimated glomerular filtration rate, and corticosteroid dose, CsA (as compared with Tac) consistently reduced MPA area under the concentration-time curve during the dosing interval at steady state overall [geometric mean ratio (GMR), 0.78 ; 95% confidence interval, 0.62-0.99] and by MPA formulation (by 22% and 21%, respectively), increased CLT/F, ss overall (1.31 ; 1.00-1.70) and by formulation (by 25% and 36%, respectively), reduced morning predose MPA concentration overall (0.59 ; 0.38-0.92) and by formulation (by 34% and 47%, respectively), increased peak-trough fluctuation overall (1.51 ; 1.06-2.17) and by formulation (by 58% and 45%, respectively), and prolonged t(max, ss) overall (adjusted median difference 0.58, 0.04- 1.12 hours) and by formulation (by 0.6 and 0.5 hours, respectively).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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