Naslov
EEG monitoring during midazolam/propofol anesthesia in children

Autori
Popović, Ljiljana ; Domijan, Marina ; Župančić, Božidar ; Antabak Anko ; Luetić, Tomislav ; Barišić Nina ;

Izvornik
Periodicum biologorum (0031-5362) 104 (2002); 103-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
electroencephalogram ( EEG); propofol; anesthesia; children

Sažetak
Propofol is rapid, short acting intravenous anesthetic which acts by blocking the access of information to the cerebral cortex via the gamma-aminobutyric acid ( GABA) receptor. There has been reports of rare excitatory adverse effects 8 including epileptic activity), especially in children after use of propofol. The aim of this study was to determine the effect of propofol on electroencephalogram in children during anesthesia procedure. Forty children, undergoing diagnostic urological procedures were randomized into two groups. One group received propofol for induction and maintenance of anesthesia and nasally administered midazolam before induction. The control group received thiopental for induction and halothane for maintenance. No epileptic discharges or excitatory adverse effects were observed in our study. On the basis of our results we may conclude that adequate doses of propofol together with midazolam dedication will not produce excitatory adverse effects or epileptogenic EEG activity in children.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA