Naslov
Antibiotic susceptibility of Helicobacter pylori in Croatian children

Autori
Lukić-Grlić, Amarela ; Hojsak, Iva ; Grbavac, Jasna ; Mišak, Zrinjka ; Jadrešin, Oleg ; Jaklin Kekez, Alemka ; Kolaček, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract & Poster Book / - , 2012

Skup
3rd Southeast European Conference on Chemotherapy and Infection

Mjesto i datum
Dubrovnik, Hrvatska, 08.11.2012. - 11.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antibiotic susceptibility; Helicobacter pylori; children
(antibiotic susceptibility; Helicobacter pylori; children)

Sažetak
Helicobacter pylori is a major cause of peptic ulcer and chronic gastritis in adults and children. According to recent guidelines, the first line treatment of H.pylori infection in children consists of a combination of clarithromycin or metronidazole, with amoxicillin, plus a proton pump inhibitor. The aiem of this study is to present the results of antibiotic susceptibility testing of H.pylori strains isolated from children in Croatia during 10-year period. Antibiotic susceptibility was determined in H.pylori strains isolated from children who underwent upper gastrointestinal endoscopy from January 2001 to December 2010 at the Children's Hospital Zagreb.The susceptibility testing was performed for amoxicillin, azithromycin, metronidazole and clarithromycin using E-test (AB Biodisk, Solna, Sweden). Out of 169 tested isolates, 131 (77.5%) were susceptible to all four tested antibiotics. To amoxicillin 99.4% isolates were susceptible. The resistance rate was 17% to azithroycin, 9% to metronidazole and 11.5% to clarithromycin. Multiple resistance was found in 12.4% (21/169) isaolates. According to our results the use of amoxicillin-metronidazole-based regimen is recommended as the first-line therapy in our study population.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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