Pregled bibliografske jedinice broj: 728951
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties // Chemistry : a European journal, 20 (2014), 52; 17296-17299 doi:10.1002/chem.201404448 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 728951 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties
Autori
Sommer, Michael ; Kureljak, Petra ; Urankar, Damijana ; Schweinfurth, David ; Stojanović, Nikolina ; Bubrin, Martina ; Gazvoda, Martin ; Osmak, Maja ; Sarkar, Biprajit ; Košmrlj, Janez
Izvornik
Chemistry : a European journal (0947-6539) 20
(2014), 52;
17296-17299
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Azocarboxamide; N; N ligands; N; O ligands; Ruthenium; Cancer
Sažetak
Azocarboxamide (azcH) has been combined for the first time with [Ru–Cym] to generate metal complexes with N, N- and N, O-coordination mode, [(Cym)Ru(azc)Cl] and [(Cym)Ru(azcH)Cl]+[PF6]. Geometric and electronic structures of the complexes are reported along with their in vitro activities against different tumour cell lines and preliminary results on solution chemistry.Compound [(Cym)Ru(azc)Cl] exhibited remarkable cytotoxic properties. It was cell-type specific and had comparable IC50 values towards both cancer cells and their drug-resistant subline. A tenfold increase in the sensitivity towards[(Cym)Ru(azc)Cl] was noted for the tumour cells with depleted intracellular glutathione (GSH) level, suggesting the essential role of GSH in cell response to this compound.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Osmak, Maja, MZOS ) ( CroRIS)
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Ambriović Ristov, Andreja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
